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Tyra Biosciences (TYRA) Stock Fundamentals, Analysis & Risk Signals

Health score, price, valuation, risk signals, and key metrics at a glance.

Tyra Biosciences
NasdaqGS•Healthcare•Biotechnology
$24.35-1.08(-0.04%)Pre-market
Market Cap
$1.61B
P/B
4.6x

Tyra Biosciences, Inc., a clinical-stage biotechnology company, develops precision medicines for fibroblast growth factor receptor (FGFR) biology in the United States. The company offers SNÅP, a precision medicine platform that enables drug design through iterative molecular snapshots to predict genetic alterations for developing therapies targeting oncology and genetically defined conditions. Its lead product candidate is FGFR3, which is in clinical trials for the treatment of patients with metastatic urothelial carcinoma and other solid tumors. The company is also developing TYRA-300 for skeletal conditions, including achondroplasia, hypochondroplasia, dysplasia, and other FGFR3-driven genetic syndromes; TYRA-200, a candidate in clinical trial for intrahepatic cholangiocarcinoma; and TYRA-430 for the treatment of hepatocellular carcinoma. Tyra Biosciences, Inc. was incorporated in 2018 and is headquartered in Carlsbad, California.

D

How this company scores

WeakMetricSide Score: 31/100

Strongest: Balance Sheet & Red Flags (15/25); weakest: Profitability (4/25).

Profitability4/25
Growth6/25
Balance Sheet & Red Flags15/25
Cash & Earnings Quality6/25
Strengths
Interest easily coveredNet cash position

Valuation vs. 5-year range

Today's multiple positioned against its own trailing range — a visual premium/discount check.

P/B · 4.6x5y range 0.6x – 5.9x
P/B 4.6x · above its 20-quarter median

Currently above its 20-quarter median.

Watch items

Data-driven signals worth keeping an eye on across the last 8 quarters

High Risk

Margin Pressure

Red Flag

The company posted negative operating margins in recent quarters — core operations are unprofitable.

Earnings Quality

Red Flag

Free cash flow has been negative in 8 of the last 8 quarters — earnings are not translating to cash.

Price & Volume
Market Cap $1.61B

Metrics at a Glance

as of June 2026

Revenue & Profit

Revenue, EBITDA, operating income, net income, EPS, and shares

TTM Revenue
$0
Q. Revenue
$0
TTM EBITDA
$-159.92M
7Q
TTM Op. Income
$-160.46M
7Q
Q. Op. Income
$-49.00M
4Q
TTM Net Income
$-148.56M
7Q
Q. Net Income
$-45.56M
4Q
EPS
$-0.69
4Q
Shares Out.
$65.99M
7Q
$0 in TTM revenue was flat at zero YoY, reaching $0 last quarter. TTM EBITDA of $-159.92M and TTM operating income of $-160.46M show growth is flowing through to the bottom line. However, net income is negative at $148.56M — growth is not yet reaching the bottom line.

Margins

Gross, EBITDA, operating, and net margin trends

EBITDA Margin
N/A
Op. Margin
-4900300000.0%
4Q
Net Margin
-4555800000.0%
4Q
Op. margin of -4900300000.0% is down 1755100000.0% YoY — costs are rising relative to revenue. Net margin at -4555800000.0% Across the last 8 quarters, operating margin has fallen for 4 consecutive quarters — a weakening trend.

Price Ratios

P/E, P/S, P/B, EV/EBITDA, FCF yield, and earnings yield

P/E Ratio
N/A
P/S Ratio
N/A
P/B Ratio
4.6x
2Q
P/S of 0.0x and P/B of 4.6x.

Assets & Liabilities

Total assets, cash, debt, book value, and leverage

Total Assets
$383.36M
19%
Cash
$73.83M
25%
Long-Term Debt
N/A
Book Value
$353.66M
17%
D/E Ratio
N/A
Debt/EBITDA
N/A

Cash Flow

Operating cash flow, free cash flow, FCF margin, and earnings quality

Op. Cash Flow
$-31.08M
31%
TTM Free Cash Flow
$-109.90M
7Q
FCF Margin
N/A
FCF / Net Income
0.7
4Q
TTM FCF of $-109.90M on $-31.08M in operating cash flow. The FCF / Net Income ratio of 0.7x means free cash flow covers net income — earnings are backed by cash. Across the last 8 quarters, free cash flow has fallen for 7 consecutive quarters — a weakening trend.

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Cash Burn

Red Flag

The last 8 consecutive quarters had negative FCF — the company is burning cash and may need external funding.

Share Dilution

Red Flag

Shares outstanding increased 12.1% — significant dilution, likely from stock compensation or capital raises.