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Palvella Therapeutics (PVLA) Stock Fundamentals, Analysis & Risk Signals

Health score, price, valuation, risk signals, and key metrics at a glance.

Palvella Therapeutics
NasdaqGM•Healthcare•Biotechnology
$151.43+0.21(<0.01%)Pre-market
Market Cap
$2.16B
P/B
10.0x

Palvella Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on developing and commercializing novel therapies to treat patients serious and rare genetic skin diseases. The company's lead product candidate is QTORIN rapamycin, a novel, 3.9% anhydrous topical gel that is in Phase 3 clinical trial for the treatment of microcystic lymphatic malformations, as well as in Phase 2 clinical trial to treat cutaneous venous malformations. It also develops QTORIN rapamycin for the treatment of angiokeratomas and other mTOR-driven skin diseases; and QTORIN pitavastatin for the treatment of disseminated superficial actinic porokeratosis. The company is based in Wayne, Pennsylvania.

D

How this company scores

WeakMetricSide Score: 30/100

Strongest: Balance Sheet & Red Flags (15/25); weakest: Growth (2/25).

Profitability8/25
Growth2/25
Balance Sheet & Red Flags15/25
Cash & Earnings Quality5/25
Strengths
Long cash runwayInterest easily coveredNet cash position

Valuation vs. 5-year range

Today's multiple positioned against its own trailing range — a visual premium/discount check.

P/S · 4700.5x5y range 0.5x – 4700.5x
P/S 4700.5x · above its 16-quarter median

Currently above its 16-quarter median.

P/B · 10.0x5y range 0.4x – 520.2x
P/B 10.0x · below its 20-quarter median

Currently below its 20-quarter median.

Watch items

Data-driven signals worth keeping an eye on across the last 8 quarters

High Risk

Margin Pressure

Red Flag

The company posted negative operating margins in recent quarters — core operations are unprofitable.

Earnings Quality

Red Flag

Free cash flow has been negative in 7 of the last 8 quarters — earnings are not translating to cash.

Price & Volume
Market Cap $2.16B

Metrics at a Glance

as of June 2026

Revenue & Profit

Revenue, EBITDA, operating income, net income, EPS, and shares

TTM Revenue
$0
100%
Q. Revenue
$0
TTM EBITDA
$-57.74M
6Q
TTM Op. Income
$-57.74M
6Q
Q. Op. Income
$-21.41M
6Q
TTM Net Income
$-61.70M
7Q
Q. Net Income
$-21.87M
7Q
EPS
$-1.52
5Q
Shares Out.
$14.36M
7Q
$0 in TTM revenue declined 100.0% YoY, reaching $0 last quarter. TTM EBITDA of $-57.74M and TTM operating income of $-57.74M show growth is flowing through to the bottom line. However, net income is negative at $61.70M — growth is not yet reaching the bottom line. Over the past year, TTM revenue is down 100% — a steady trend.

Margins

Gross, EBITDA, operating, and net margin trends

EBITDA Margin
N/A
Op. Margin
-2140500000.0%
7Q
Net Margin
-2187000000.0%
7Q
Op. margin of -2140500000.0% is down 1215500000.0% YoY — costs are rising relative to revenue. Net margin at -2187000000.0% Across the last 8 quarters, operating margin has fallen for 7 consecutive quarters — a weakening trend.

Price Ratios

P/E, P/S, P/B, EV/EBITDA, FCF yield, and earnings yield

P/E Ratio
N/A
P/S Ratio
N/A
3Q
P/B Ratio
10.0x
91%
P/S of 0.0x and P/B of 10.0x.

Assets & Liabilities

Total assets, cash, debt, book value, and leverage

Total Assets
$253.51M
244%
Cash
$187.80M
167%
Long-Term Debt
N/A
Book Value
$216.87M
354%
D/E Ratio
N/A
Debt/EBITDA
N/A

Cash Flow

Operating cash flow, free cash flow, FCF margin, and earnings quality

Op. Cash Flow
$-12.85M
2Q
TTM Free Cash Flow
$-36.51M
5Q
FCF Margin
N/A
3Q
FCF / Net Income
0.6
8%
TTM FCF of $-36.51M on $-12.85M in operating cash flow. The FCF / Net Income ratio of 0.6x means cash covers only part of net income — earnings quality needs attention. Across the last 8 quarters, free cash flow has fallen for 5 consecutive quarters — a weakening trend.

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Revenue Decline

Red Flag

TTM revenue has contracted 100.0% — significant decline indicating deteriorating demand.

Cash Burn

Red Flag

The last 7 consecutive quarters had negative FCF — the company is burning cash and may need external funding.

Share Dilution

Red Flag

Shares outstanding increased 987.6% — significant dilution, likely from stock compensation or capital raises.