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BeOne Medicines (ONC) Stock Fundamentals, Analysis & Risk Signals

Health score, price, valuation, risk signals, and key metrics at a glance.

BeOne Medicines
NasdaqGS•Healthcare•Biotechnology
$358.26-4.42(-0.01%)Market closed
Market Cap
$512.69B
P/E
781.9x
P/S
83.7x
P/B
99.1x

BeOne Medicines AG, an oncology company, engages in discovering and developing various treatments for cancer patients in the United States, China, Europe, and internationally. The company's commercial stage products include BRUKINSA, a small molecule inhibitor of Bruton's Tyrosine Kinase (BTK) for the treatment of various blood cancers; TEVIMBRA, an anti-PD-1 antibody immunotherapy for the treatment of various solid tumor and blood cancers; SYLVANT for the treatment of adult patients with multicentric castleman disease; BAITUOWEI for patients with BC in premenopausal and perimenopausal women, and cancer; and PARTRUVIX for the treatment of various solid tumors. Its clinical stage products comprise Sonrotoclax BGB-11417, a small molecule Bcl-2 inhibitor; BGB-16673, a BTK targeting chimeric degradation activation compound active against wild type and mutant BTK; BG-60366, an EGFR-targeted CDAC; BG-89894 (SYH2039), a MAT2A Inhibitor; BGB-58067, an MTA-Cooperative PRMT5 Inhibitor; BG-T187 and BG-C0902, an anti-EGFRxMET trispecific antibody; BGB-26808, a HPK-1 Inhibitor; BGB-C354, an anti-B7H3 ADC; Zanidatamab, a bispecific HER2-targeted antibody; BG-C137, an anti-FGFR2b ADC; BGB-53038, a Pan-KRAS Inhibitor; BGB-B2033, an anti-GPC3x4-1BB bispecific antibody; BGB-B3227, an anti-MUC1xCD16A bispecific antibody; BG-C477, an anti-CEAADC; BGB-43395, a CDK4 Inhibitor; BG-68501, a CDK2 Inhibitor; BG-C9074, an anti-B7H4 ADC; BGB-21447, a Bcl-2 Inhibitor; and BGB-45035, an IRAK4-targeted CDAC. It also has various preclinical programs. The company has agreements Amgen, BMS, Bio-Thera, EUSA Pharma, Luye Pharmaceutical, and Novartis. The company was formerly known as BeiGene, Ltd. and changed its name to BeOne Medicines AG in May 2025. BeOne Medicines AG was founded in 2010 and is based in Basel, Switzerland.

A

How this company scores

ExcellentMetricSide Score: 84/100

Strongest: Profitability (23/25); weakest: Balance Sheet & Red Flags (16/25).

Profitability23/25
Growth22/25
Balance Sheet & Red Flags16/25
Cash & Earnings Quality23/25
Strengths
Growing revenueRising free cash flowStrong marginsRising earnings

Valuation vs. 5-year range

Today's multiple positioned against its own trailing range — a visual premium/discount check.

P/E · 781.9x5y range 781.9x – 6956.7x
P/E 781.9x · below its 4-quarter median

Currently below its 4-quarter median.

P/S · 83.7x5y range 62.7x – 413.8x
P/S 83.7x · near its 20-quarter median

Currently near its 20-quarter median.

P/B · 99.1x5y range 39.4x – 129.9x

Watch items

Data-driven signals worth keeping an eye on across the last 8 quarters

High Risk

Margin Pressure

Red Flag

The company posted negative operating margins in recent quarters — core operations are unprofitable.

Earnings Quality

Watch

FCF/Net Income has dropped below 0.7x in 3 quarters — monitor for earnings quality deterioration.

Price & Volume
Market Cap $512.69B

Metrics at a Glance

as of June 2026

Revenue & Profit

Revenue, EBITDA, operating income, net income, EPS, and shares

TTM Revenue
$6.13B
7Q
Q. Revenue
$1.71B
5Q
TTM EBITDA
$1.15B
7Q
TTM Op. Income
$923.10M
7Q
Q. Op. Income
$325.05M
7Q
TTM Net Income
$655.71M
7Q
Q. Net Income
$237.01M
2Q
EPS
$0.16
129%
Shares Out.
$1.45B
7Q
$6.13B in TTM revenue grew 34.3% YoY, reaching $1.71B last quarter. TTM EBITDA of $1.15B and TTM operating income of $923.10M show growth is flowing through to the bottom line. TTM net income of $655.71M means revenue is converting into profit. Across the last 8 quarters, TTM revenue has risen for 7 consecutive quarters — an improving trend.

Margins

Gross, EBITDA, operating, and net margin trends

Gross Margin
89.8%
3%
EBITDA Margin
21.4%
128%
Op. Margin
19.1%
7Q
Net Margin
13.9%
94%
Op. margin of 19.1% is up 12.4% YoY — cost efficiency is improving. Net margin at 13.9% and gross margin of 89.8% show how much of each revenue dollar survives to profit. Across the last 8 quarters, operating margin has risen for 7 consecutive quarters — an improving trend.

Price Ratios

P/E, P/S, P/B, EV/EBITDA, FCF yield, and earnings yield

P/E Ratio
781.9x
3Q
P/S Ratio
83.7x
12%
P/B Ratio
99.1x
10%
At 781.9x P/E, the stock trades above typical market levels — the market expects above-average growth. P/S of 83.7x and P/B of 99.1x provide additional context. Use the growth and margin sections to judge whether the multiple is justified. Across the last 4 quarters, P/E has fallen for 3 consecutive quarters — an improving trend.

Assets & Liabilities

Total assets, cash, debt, book value, and leverage

Total Assets
$9.18B
5Q
Cash
$5.10B
5Q
Long-Term Debt
$882.16M
451%
Book Value
$5.17B
6Q
D/E Ratio
0.2
2Q
Debt/EBITDA
2.4
104%
With $9.18B in assets and $882.16M in long-term debt, D/E is 0.2and book value is $5.17B — a conservative capital structure with a cushion to weather downturns. Across the last 7 quarters, debt/equity has fallen for 2 consecutive quarters — an improving trend.

Cash Flow

Operating cash flow, free cash flow, FCF margin, and earnings quality

Op. Cash Flow
$462.82M
76%
TTM Free Cash Flow
$1.33B
7Q
FCF Margin
21.7%
7Q
FCF / Net Income
2.0
3Q
TTM FCF of $1.33B on $462.82M in operating cash flow. The FCF / Net Income ratio of 2.0x means free cash flow covers net income — earnings are backed by cash. Across the last 8 quarters, free cash flow has risen for 7 consecutive quarters — an improving trend.

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P/B 99.1x
· above its 20-quarter median

Currently above its 20-quarter median.

Leverage Risk

Watch

Debt-to-equity has risen 272.5% recently — increasing financial risk even if the current ratio is manageable.

Cash Burn

Watch

FCF turned negative in 2 of the last 8 quarters — occasional cash consumption.

Share Dilution

Red Flag

Shares outstanding increased 5.4% — significant dilution, likely from stock compensation or capital raises.