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Anavex Life Sciences (AVXL) Stock Fundamentals, Analysis & Risk Signals

Health score, price, valuation, risk signals, and key metrics at a glance.

Anavex Life Sciences
NasdaqGS•Healthcare•Biotechnology
$2.65-0.10(-0.04%)Market open
Market Cap
$223.40B
P/B
1986.7x

Anavex Life Sciences Corp. operates as a biopharmaceutical company. It engages in developing innovative treatments for Alzheimer's disease, Parkinson's disease, schizophrenia, neurodevelopmental, neurodegenerative, and rare diseases, including Rett syndrome, and other central nervous system (CNS) disorders, pain, and various types of cancer . Its lead drug candidate, ANAVEX 2-73 (blarcamesine), has completed a Phase 2a and a Phase 2b/3 clinical trial for Alzheimer's disease; a Phase 2 proof-of-concept study in Parkinson's disease dementia; and a Phase 2 and a Phase 3 study in adult patients and one Phase 2/3 study in pediatric patients with Rett syndrome. Its ANAVEX 2-73 is an orally available drug candidate designed to restore cellular homeostasis by targeting SIGMAR1 and muscarinic receptors. The ANAVEX 2-73 also exhibited anticonvulsant, anti-amnesic, neuroprotective, and anti-depressant properties in animal models, indicating its potential to treat additional CNS disorders, including epilepsy. The company's ANAVEX 3-71, which targets SIGMAR1 and M1 muscarinic receptors, is a clinical stage drug candidate demonstrating disease-modifying activity against Alzheimer's disease in transgenic (3xTg-AD) mice, including cognitive deficits, amyloid, and tau pathologies. Anavex Life Sciences Corp. was incorporated in 2004 and is headquartered in New York, New York.

C

How this company scores

AverageMetricSide Score: 46/100

Strongest: Profitability (17/25); weakest: Growth (6/25).

Profitability17/25
Growth6/25
Balance Sheet & Red Flags15/25
Cash & Earnings Quality8/25
Strengths
Long cash runwayInterest easily coveredProfit converts from growthNet cash position

Valuation vs. 5-year range

Today's multiple positioned against its own trailing range — a visual premium/discount check.

P/B · 1986.7x5y range 2.1x – 1986.7x
P/B 1986.7x · above its 20-quarter median

Currently above its 20-quarter median.

Watch items

Data-driven signals worth keeping an eye on across the last 8 quarters

High Risk

Margin Pressure

Red Flag

The company posted negative operating margins in recent quarters — core operations are unprofitable.

Earnings Quality

Red Flag

Free cash flow has been negative in 8 of the last 8 quarters — earnings are not translating to cash.

Price & Volume
Market Cap $223.40B

Metrics at a Glance

as of June 2026

Revenue & Profit

Revenue, EBITDA, operating income, net income, EPS, and shares

TTM Revenue
$0
Q. Revenue
$0
TTM EBITDA
$-17.37M
6Q
TTM Op. Income
$-17.37M
6Q
Q. Op. Income
$6.74M
4Q
TTM Net Income
$-13.02M
4Q
Q. Net Income
$7.82M
4Q
EPS
$0.08
150%
Shares Out.
$92.70B
7Q
$0 in TTM revenue was flat at zero YoY, reaching $0 last quarter. TTM EBITDA of $-17.37M and TTM operating income of $-17.37M show growth is flowing through to the bottom line. However, net income is negative at $13.02M — growth is not yet reaching the bottom line.

Margins

Gross, EBITDA, operating, and net margin trends

EBITDA Margin
N/A
Op. Margin
673700000.0%
4Q
Net Margin
782400000.0%
4Q
Op. margin of 673700000.0% is up 2119600000.0% YoY — cost efficiency is improving. Net margin at 782400000.0% Across the last 8 quarters, operating margin has risen for 4 consecutive quarters — an improving trend.

Price Ratios

P/E, P/S, P/B, EV/EBITDA, FCF yield, and earnings yield

P/E Ratio
N/A
P/S Ratio
N/A
P/B Ratio
1986.7x
22855%
P/S of 0.0x and P/B of 1986.7x.

Assets & Liabilities

Total assets, cash, debt, book value, and leverage

Total Assets
$120.14M
2Q
Cash
$118.33M
2Q
Long-Term Debt
N/A
Book Value
$112.45M
2Q
D/E Ratio
N/A
Debt/EBITDA
0.0

Cash Flow

Operating cash flow, free cash flow, FCF margin, and earnings quality

Op. Cash Flow
$-9.10M
27%
TTM Free Cash Flow
$-29.29M
3Q
FCF Margin
N/A
FCF / Net Income
2.2
5Q
TTM FCF of $-29.29M on $-9.10M in operating cash flow. The FCF / Net Income ratio of 2.2x means free cash flow covers net income — earnings are backed by cash. Across the last 8 quarters, free cash flow has risen for 3 consecutive quarters — an improving trend.

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Cash Burn

Red Flag

The last 8 consecutive quarters had negative FCF — the company is burning cash and may need external funding.

Share Dilution

Red Flag

Shares outstanding increased 109219.0% — significant dilution, likely from stock compensation or capital raises.